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DIABETES, LIPIDS AND METABOLISM LABORATORY

UNIVERSIDAD DE LOS ANDES

Carrera 1 No 18 A-12   -  Z125 - Bogotá, Colombia
Phone (57-1) 3324282 Ext: 3780

e-mail: cmendivi@uniandes.edu.co

INSTITUTIONAL REGULATIONS

Universidad de los Andes | Vigilada Mineducación

Reconocimiento como Universidad: Decreto 1297 del 30 de mayo de 1964.

Reconocimiento personería jurídica: Resolución 28 del 23 de febrero de 1949 Minjusticia.

Diabetes, Lipids and Metabolism Laboratory

OWN PROJECTS

Validation of three indirect V̇O2max assessments at 2600 m altitude​

Current status: Active

Impact of acetylcarnitine and lipoic acid, alone or in combination, on physical performance, mitochondrial function and HDL functionality in physically active adults: Controlled clinical trial

Current status: Active

This is the winning project of the Joint Research Call- 2017 (Uniandes-FSFB) for research projects related to health.

It is essential to identify molecules that increase or enhance the impact of exercise on mitochondrial metabolism, thereby improving cardiorespiratory fitness, protective lipoprotein (HDL) functionality, and molecular phenomena that govern energy production. This strategy could have great impact in reducing cardiometabolic morbidity and mortality. Thus, the aim of this project is to answer the question: Can supplementation with lipoic acid (1200 mg / day) or a bioabsorbable carnitine salt (acetylcarnitine, 4 g / day) separately or together improve cardiorespiratory fitness, the main predictor of cardiometabolic risk in adults between 18 and 55 years of age?

Effects of combined oral contraceptives containing different progestins on plasma lipids and metabolic variables in reproductive-age women: a systematic review and meta-analysis

Current status: Active

Estrogens and progestins have contrasting effects on glucose and lipid metabolism. Nevertheless, given that each available OC has a distinct combination and dose of estrogen and progestin, the impact of each OC on relevant metabolic variables is not easy to predict.
For this reason, we will undertake a meta-analysis of randomized clinical trials in order to estimate a consolidated effect of several OC on body weight, glycemic levels, insulin resistance and the plasma lipid profile.

Determination of Apolipoprotein CIII and E levels in HDL cholesterol fractions, concentration and enzyme activity of LPL, LCAT and CETP in patients with different cardiovascular risk profiles.​​

Current status: Active

 

This project aims to quantify the levels and enzyme activity of lecithin-cholesterol acyl transferase (LCAT), lipoprotein lipase (LPL) and cholesterol esther transfer protein (CETP), enzymes directly involved in high-density lipoprotein metabolism. HDL are separated and classified by their apoC-III and apo-E content, and by their size, and the concentration and activity of each of these key enzymes is determined in each of the HDL subtypes, in people with or without metabolic disturbances.

The goal is to find explanations as to why the different HDL subtypes are generated, and shed light on the process of reverse cholesterol transport.

 

Plasma levels of proprotein convertase subtilisin / kexin type 9 (PCSK9) as a prognostic factor after acute myocardial infarction

Current status: Active

This is a winning project of the 2016 open call for health-related research projects of Fundación Santa Fe de Bogotá and Universidad de los Andes. It is being developed between January 2016 and December 2017.

The aim of this study was to determine the association between plasma levels of PCSK9 post-infarction with the development of systolic heart failure at 3 months. In addition secondarily the association between plasma levels of PCSK9 infarction with the prevalence of major adverse cardiac events within 3 months after the ischemic event is determined.

 

Identification and validation of new biomarkers of insulin resistance in Colombian population

Current status:  Finalized – Publication process

This project was awarded a grant in the 2014 Colciencias Health Sciences Research Call. Its planned execution timeframe is January 2015 - December 2016.

The main aim of the project is to identify serum biomarkers for the early detection of insulin resistance in otherwise healthy people, before they develop diabetes complications or perhaps even hyperglycemia. This project links the pathophysiology of insulin resistance and Diabetes Mellitus with the need to improve population health through opportune detection and intervention